The adjusted VE of 2 doses (measured ≥7 days after the second dose) was 94% (95% CI = 87%–97%). Interim analyses indicated that the VE of a single dose (measured 14 days after the first dose through 6 days after the second dose) was 82% (95% confidence interval = 74%–87%), adjusted for age, race/ethnicity, and underlying medical conditions. A test-negative case-control study is underway to evaluate mRNA COVID-19 vaccine effectiveness (VE) against symptomatic illness among HCP at 33 U.S. Early distribution of two mRNA COVID-19 vaccines (Pfizer-BioNTech and Moderna) to HCP allowed assessment of the effectiveness of these vaccines in a real-world setting. The Advisory Committee on Immunization Practices recommended prioritization of HCP for COVID-19 vaccination to maintain provision of critical services and reduce spread of infection in health care settings ( 2). Throughout the COVID-19 pandemic, health care personnel (HCP) have been at high risk for exposure to SARS-CoV-2, the virus that causes COVID-19, through patient interactions and community exposure ( 1). Magill, MD, PhD 1 Jennifer Verani, MD 1 Stephanie Schrag, DPhil 1 Vaccine Effectiveness Among Healthcare Personnel Study Team ( View author affiliations) View suggested citation Babcock, MD 33 Nasia Safdar, MD, PhD 34 ,35 Marc Fischer, MD 1 Rosalyn Singleton, MD 36 Nora Chea, MD 1 Shelley S. Debes, PhD 30 Michael Lin, MD 31 Jeanmarie Mayer, MD 32 Hilary M. Phipps, DVM 24 ,25 Ghinwa Dumyati, MD 26 Rebecca Pierce, PhD 27 Tiffanie M. Henning, MD 15 Frank LoVecchio, DO 16 Joelle Nadle, MPH 17 Devra Barter, MSc 18 Monica Brackney, MS 19 Amber Britton, MPH 20 ,21 Kaytlynn Marceaux-Galli, MPH 22 Sarah Lim, MBBCh 23 Erin C. Schrading, MD 13 Brian Chinnock, MD 14 Daniel J. Haran, MD, PhD 11 Utsav Nandi, MD 12 Walter A. Beiser, MD 10 Brett Faine, PharmD 2 John P. Moran, MD 3 Elizabeth Krebs, MD 8 Mark Steele, MD 9 David G. Talan, MD 3 Anusha Krishnadasan, PhD 3 Karisa K. Farrar, MPH 1 Ryan Gierke, MPH 1 Nicholas M. Please note: This report has been corrected.
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